Endosomal recycling reconciles the Alzheimer’s disease paradox
Scott A. Small, Gregory A. Petsko
Abstract
A hub-and-spoke model with endosomal recycling as the hub can reconcile the pathogenic contribution of amyloid precursor protein to Alzheimer's disease.
Topics & Concepts
EndosomeDiseaseAlzheimer's diseaseAmyloid (mycology)Amyloid precursor proteinNeuroscienceCell biologyChemistryBiologyMedicinePathologyIntracellularAlzheimer's disease research and treatmentsCellular transport and secretionLipid Membrane Structure and Behavior