Bent into shape: Folded peptides to mimic protein structure and modulate protein function
Haley I. Merritt, Nicholas Sawyer, Paramjit S. Arora
Abstract
Protein secondary and tertiary structure mimics have served as model systems to probe biophysical parameters that guide protein folding and as attractive reagents to modulate protein interactions. Here we review contemporary methods to reproduce loop, helix, sheet and coiled-coil conformations in short peptides.
Topics & Concepts
Protein foldingProtein tertiary structureProtein structureFolding (DSP implementation)Coiled coilProtein secondary structureBiophysicsBeta sheetChemistryHelix (gastropod)BiologyBiochemistryEngineeringElectrical engineeringEcologySnailChemical Synthesis and AnalysisProtein Structure and DynamicsGlycosylation and Glycoproteins Research