Alkylboronic acids as alkylating agents: photoredox-catalyzed alkylation reactions assisted by K<sub>3</sub>PO<sub>4</sub>
Fuyang Yue, Henan Ma, Hongjian Song, Yuxiu Liu, Jianyang Dong, Qingmin Wang
Abstract
P NMR spectroscopy, and other techniques. In addition, we describe a simple and reliable alkylation method that has good functional group tolerance and can be used for direct C-B chlorination, cyanation, vinylation, alkynylation, and allylation, as well as late-stage functionalization of derivatized drug molecules. Notably, alkylboronic acids can be selectively activated in the presence of a boronic pinacol ester.
Topics & Concepts
AlkylationCatalysisChemistryPhotoredox catalysisCombinatorial chemistryMedicinal chemistryOrganic chemistryPhotocatalysisRadical Photochemical ReactionsSulfur-Based Synthesis TechniquesFluorine in Organic Chemistry