CXCL5 overexpression predicts a poor prognosis in pancreatic ductal adenocarcinoma and is correlated with immune cell infiltration
Ronghua Zhang, Qiaofei Liu, Junya Peng, Mengyi Wang, Tong Li, Jingkai Liu, Ming Cui, Xiang Zhang, Xiang Gao, Quan Liao, Yupei Zhao
Abstract
Background: C-X-C motif chemokine 5 (CXCL5) is an important attractant for immune cell accumulation in tumor tissues. Recent evidence has shown that CXCL5 could promote carcinogenesis and cancer progression in a variety of cancer types. However, the relationships between CXCL5, immune cell infiltration and pancreatic ductal adenocarcinoma (PDAC) remain largely unknown. This study aimed to explore the role and regulative mechanism of CXCL5 in PDAC carcinogenesis.
Topics & Concepts
CXCL5Pancreatic cancerCancer researchImmune systemCarcinogenesisMedicineChemokineImmunohistochemistryMetastasisBiologyPathologyCancerInternal medicineImmunologyPancreatic and Hepatic Oncology ResearchCancer Immunotherapy and BiomarkersChemokine receptors and signaling