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The volume-regulated anion channel LRRC8C suppresses T cell function by regulating cyclic dinucleotide transport and STING–p53 signaling

Axel R. Concepcion, Larry E. Wagner, Jingjie Zhu, Anthony Tao, Jun J. Yang, Alireza Khodadadi‐Jamayran, Yin‐Hu Wang, Menghan Liu, Rebecca E. Rose, Rebecca Jones, William A. Coetzee, David I. Yule, Stefan Feske

2022Nature Immunology127 citationsDOIOpen Access PDF

Topics & Concepts

StingCell biologyFunction (biology)Ion channelSignal transductionChemistryBiologyBiochemistryPhysicsReceptorThermodynamicsinterferon and immune responsesRNA regulation and diseaseRNA modifications and cancer
The volume-regulated anion channel LRRC8C suppresses T cell function by regulating cyclic dinucleotide transport and STING–p53 signaling | Litcius