Chemoenzymatic one-pot reaction from carboxylic acid to nitrile <i>via</i> oxime
Melissa Horvat, Victoria Weilch, Robert Rädisch, Sebastian Hecko, Astrid Schiefer, Florian Rudroff, Birgit Wilding, Norbert Klempier, Miroslav Pátek, Ludmila Martı́nková, Margit Winkler
Abstract
oxime formation. The final step to the nitrile is catalyzed by aldoxime dehydratase (Oxd). Full conversions of phenylacetic acid and hexanoic acid were achieved in a two-phase mode.
Topics & Concepts
OximeNitrileDehydrataseChemistryAldehydeCarboxylic acidCatalysisDehydrationOrganic chemistryEnzymeCombinatorial chemistryBiochemistryEnzyme Catalysis and ImmobilizationAmino Acid Enzymes and MetabolismMicrobial Metabolic Engineering and Bioproduction