Prognostic impact of PD-L1 in oropharyngeal cancer after primary curative radiotherapy and relation to HPV and tobacco smoking
Jacob Kinggaard Lilja‐Fischer, Jesper Grau Eriksen, Jeanette Bæhr Georgsen, Thao Vo, Stine Rosenkilde Larsen, Jonathan D. Cheng, Michael Busch-Sørensen, Deepti Aurora-Garg, Torben Steiniche, Jens Overgaard
Abstract
PD-L1 expression had no prognostic significance in OPSCC patients treated with primary radiotherapy alone. A substantial proportion of OPSCC tumors show PD-L1 overexpression, especially in HPV p16+ tumors in patients with little or no smoking history.
Topics & Concepts
MedicineInternal medicineHazard ratioOncologyImmunohistochemistryRadiation therapyConfidence intervalIncidence (geometry)Head and neck cancerCancerCohortHead and neck squamous-cell carcinomaImmunotherapyPhysicsOpticsCancer Immunotherapy and BiomarkersHead and Neck Cancer StudiesEsophageal Cancer Research and Treatment