ICG/<scp>l</scp>-Arginine Encapsulated PLGA Nanoparticle-Thermosensitive Hydrogel Hybrid Delivery System for Cascade Cancer Photodynamic-NO Therapy with Promoted Collagen Depletion in Tumor Tissues
Zhiting Sun, Xiaoxiao Wang, Jing Liu, Zhihong Wang, Weiwei Wang, Deling Kong, Xigang Leng
Abstract
could activate matrix metalloproteinases (MMPs), which notably degraded collagen in ECM so as to damage the tumor microenvironment. PLGA@ICG@l-Arg/Gel significantly increased the antitumor efficacy against highly malignant 4T1 tumors in mice. Taken together, PLGA@ICG@l-Arg/Gel is a multifunctional platform that provides a novel strategy for cancer treatment with cascade amplification of the ROS oxidation effect, which holds great potential in clinical translation.
Topics & Concepts
Photodynamic therapyPLGAChemistryReactive oxygen speciesDrug deliveryCancer cellMatrix metalloproteinaseTumor microenvironmentCancer researchPeroxynitriteBiophysicsCancerBiochemistryMedicineSuperoxideIn vitroInternal medicineTumor cellsEnzymeBiologyOrganic chemistryNanoplatforms for cancer theranosticsPhotodynamic Therapy Research StudiesCancer, Hypoxia, and Metabolism