Destructive Role of TMAO in T-Tubule and Excitation-Contraction Coupling in the Adult Cardiomyocytes
Bu Jin, Fangfang Ji, Anjun Zuo, Huiting Liu, Lin Qi, Yun He, Qingyao Wang, Peng Zhao
Abstract
handling dysfunction in cardiomyocytes under the TMAO stress via promoting tubulin densification and polymerization and therefore Junctophilin-2 (JPH2) redistribution. Mice treated with TMAO represented cardiac dysfunction and T-tubule network disorganization.TMAO impairs cardiac function via the promotion of tubulin polymerization, subsequent translocation of JPH2, and T-tubule remodeling, which provides a novel mechanism for the relationship between HF and elevated TMAO.
Topics & Concepts
MedicineTubuleHeart failureConfocal microscopyCell biologyPathologyBiophysicsInternal medicineBiologyKidneyNitric Oxide and Endothelin EffectsCardiac Fibrosis and RemodelingCardiac Ischemia and Reperfusion