Cystine transporter regulation of pentose phosphate pathway dependency and disulfide stress exposes a targetable metabolic vulnerability in cancer
Xiaoguang Liu, Kellen Olszewski, Yilei Zhang, Esther W. Lim, Jiejun Shi, Xiaoshan Zhang, Jie Zhang, Hyemin Lee, Pranavi Koppula, Guang Lei, Zhuang Li, M. James You, Bingliang Fang, Wei Li, Christian M. Metallo, Masha V. Poyurovsky, Boyi Gan
Topics & Concepts
Pentose phosphate pathwayCell biologyTransporterBiochemistryCystineChemistryDisulfide bondCancer cellMetabolismCancerBiologyGlycolysisEnzymeGeneGeneticsCysteineBiomedical Research and PathophysiologyAmino Acid Enzymes and MetabolismCancer, Hypoxia, and Metabolism