Fructose induced KHK-C can increase ER stress independent of its effect on lipogenesis to drive liver disease in diet-induced and genetic models of NAFLD
Sehyung Park, Robert N. Helsley, Taghreed Fadhul, Jennifer L. S. Willoughby, Leila Noetzli, Ho-Chou Tu, Marie H. Solheim, Shiho Fujisaka, Hui Pan, Jonathan M. Dreyfuss, Joanna Bons, Jacob Rose, Christina D. King, Birgit Schilling, Aldons J. Lusis, Calvin Pan, Manoj K. Gupta, Rohit Kulkarni, Kevin Fitzgerald, Philip A. Kern, Senad Divanovic, C. Ronald Kahn, Samir Softic
Topics & Concepts
Fatty liverInternal medicineEndocrinologyLipogenesisDownregulation and upregulationMetabolic syndromeFructoseGene knockdownInsulin resistanceMedicineSteatosisBiologyObesityDiseaseLipid metabolismBiochemistryGeneLiver Disease Diagnosis and TreatmentDiet, Metabolism, and DiseaseEndoplasmic Reticulum Stress and Disease