Highly Potent and Selective Dopamine D<sub>4</sub> Receptor Antagonists Potentially Useful for the Treatment of Glioblastoma
Pegi Pavletić, Ana Semeano, Hideaki Yano, Alessandro Bonifazi, Gianfabio Giorgioni, Alessandro Piergentili, Wilma Quaglia, Maria Giovanna Sabbieti, Dimitrios Agas, Giorgio Santoni, Roberto Pallini, Lucia Ricci‐Vitiani, Emanuela Sabato, Giulio Vistoli, Fabio Del Bello
Abstract
induced an increased effect in reducing the cell viability with respect to temozolomide, which is the first-choice chemotherapeutic drug in GBM.
Topics & Concepts
ChemistryTemozolomideAntagonistDopamine receptor D2ReceptorDopamineGlioblastomaPharmacologyViability assayIn vitroCancer researchStereochemistryBiochemistryNeuroscienceBiologyReceptor Mechanisms and SignalingPharmacological Receptor Mechanisms and EffectsProtein Degradation and Inhibitors