Structural Optimization of Polymeric Carriers to Enhance the Immunostimulatory Activity of Molecularly Defined RIG-I Agonists
Max E. Jacobson, Kyle W. Becker, Christian R. Palmer, Lucinda E. Pastora, R. Brock Fletcher, Kathryn A. Collins, Olga Fedorova, Craig L. Duvall, Anna Marie Pyle, John T. Wilson
Abstract
in major clearance organs, effects that were dependent on polymer composition. Collectively, these studies have yielded novel polymeric carriers designed and optimized specifically to enhance the delivery and activity of 3pRNA with potential to advance the clinical development of RIG-I agonists.
Topics & Concepts
MonomerIntracellularNucleic acidChemistryAlkylBiophysicsRNAEndosomePolymerBiochemistryCombinatorial chemistryBiologyOrganic chemistryGeneinterferon and immune responsesRNA Interference and Gene DeliveryImmune Response and Inflammation