Simulating drug concentrations in PDMS microfluidic organ chips
Jennifer Grant, Aliçan Özkan, Crystal Yuri Oh, Gautam Mahajan, Rachelle Prantil‐Baun, Donald E. Ingber
Abstract
microfluidic model to simulate the spatial and temporal gradient of a drug in 3D without prior knowledge of the partition coefficient or the rate of diffusion in PDMS. Thus, this approach may expand the use of PDMS Organ Chip devices for various forms of drug testing.
Topics & Concepts
PolydimethylsiloxaneMicrofluidicsDrugNanotechnologyMaterials scienceAbsorption (acoustics)PharmacologyMedicineComposite material3D Printing in Biomedical ResearchInnovative Microfluidic and Catalytic Techniques InnovationMicrofluidic and Capillary Electrophoresis Applications