Bioorthogonal activation of prodrugs, for the potential treatment of breast cancer, using the Staudinger reaction
Madonna M. A. Mitry, Samuel Y. Boateng, Francesca Greco, Helen M. I. Osborn
Abstract
-acetylated-9-azido sialic acid showing ∼17-fold higher azide expression on the former. Taken together, these data demonstrate the feasibility of the Staudinger reaction for selective activation of prodrugs targeted to the MCF-7 breast cancer cells.
Topics & Concepts
Bioorthogonal chemistryProdrugSialic acidChemistryAzideBiochemistryClick chemistryCombinatorial chemistryOrganic chemistryClick Chemistry and ApplicationsCancer Research and TreatmentsGlycosylation and Glycoproteins Research