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A metal–organic framework neuron

Zheng Li, M. Chen, Qingqing Wu, Yuan Cheng, Jing‐Juan Xu, Hong‐Yuan Chen, Weiwei Zhao

2025National Science Review22 citationsDOIOpen Access PDF

Abstract

The demand for deep human-machine fusion propels the development of artificial neurons. However, emulating the neuronal spiking in aqueous environments remains challenging. Metal-organic frameworks (MOFs) have recently shown promise in neuromorphic engineering compatible with aqueous operation. Here, we report a MOF neuron with real neurotransmitter-dopamine (DA)-tunable spikes for the first time. Based on the DA mediation, some sophisticated neuronal functions, including integration-and-firing, synaptic facilitation-induced spike broadening and DA-tunable spiking number and width, were mimicked. DA-mediated spikes in this MOF neuron were further implemented to exquisitely control peripheral equipment. This work introduces the concept of a MOF neuron interfaced with a real neurotransmitter in fluids, providing a new perspective for artificial neuron development.

Topics & Concepts

NeuronNeuromorphic engineeringComputer scienceBiological neuron modelNeuroscienceNeurotransmitterArtificial neuronDopamineNanotechnologyArtificial intelligenceMaterials scienceArtificial neural networkBiologyCentral nervous systemAdvanced Memory and Neural ComputingLuminescence and Fluorescent MaterialsMetal-Organic Frameworks: Synthesis and Applications
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