Development and validation of RP-HPLC method for quantification of repaglinide in mPEG-PCL polymeric nanoparticles: QbD-driven optimization, force degradation study, and assessment of in vitro release mathematic modeling
Geetika Wadhwa, Kowthavarapu Venkata Krishna, Sunil Kumar Dubey, Rajeev Taliyan
Topics & Concepts
RepaglinideChromatographyPolycaprolactoneHigh-performance liquid chromatographyMaterials sciencePolyethylene glycolTaguchi methodsDegradation (telecommunications)Quality by DesignChemistryPolymerInsulinComputer scienceComposite materialOrganic chemistryEndocrinologyMedicineMetforminParticle sizeTelecommunicationsPhysical chemistryAnalytical Methods in PharmaceuticalsDrug Solubulity and Delivery SystemsAnalytical Chemistry and Chromatography