Autophagy involvement in oncogenesis
Satoru Torii, Shinya Honda, Michiko Murohashi, Hirofumi Yamaguchi, Shigeomi Shimizu
Abstract
Various clinical and experimental findings have revealed the causal relationship between autophagy failure and oncogenesis, and several mechanisms have been suggested to explain this relationship. We recently proposed two additional mechanisms: centrosome number dysregulation and the failure of autophagic cell death. Here, we detail the mechanical relationship between autophagy failure and oncogenesis.
Topics & Concepts
AutophagyCarcinogenesisCentrosomeBiologyCell biologyProgrammed cell deathCancer researchCellApoptosisGeneticsCell cycleCancerAutophagy in Disease and TherapyPlant responses to water stress