Discovery of a PROTAC targeting ALK with in vivo activity
Guoyi Yan, Xin-Xin Zhong, Yue Lin, Chunlan Pu, Huifang Shan, Suke Lan, Meng Zhou, Xueyan Hou, Jie Yang, Rui Li
Topics & Concepts
Anaplastic lymphoma kinaseChemistryIn vivoIn vitroUbiquitin ligaseALK inhibitorProteolysisDrug discoveryCereblonCell cultureCancer researchUbiquitinPharmacologyBiochemistryBiologyEnzymeGeneLung cancerOncologyMalignant pleural effusionGeneticsBiotechnologyMedicineProtein Degradation and InhibitorsUbiquitin and proteasome pathwaysPeptidase Inhibition and Analysis