Cobaltoceniumselenolate Gold(I) Complexes: Synthesis, Spectroscopic, Structural and Anticancer Properties
Daniel Menia, Holger Kopacka, Klaus Wurst, Thomas Müller, Petra Lippmann, Ingo Ott, Benno Bildstein
Abstract
Abstract Cobaltoceniumselenolate is an unusual, highly air‐sensitive, mesoionic compound containing a very soft anionic selenium donor atom. Here we explore its coordination chemistry with Au(I) metal centers and show that its hetero‐ and homoleptic gold complexes are highly colored, air‐stable compounds, which were characterized by 1 H/ 13 C/ 31 P/ 77 Se NMR, IR, UV‐Vis, HR‐MS and single crystal XRD. Cytotoxicity of these polar, water‐soluble complexes was studied against various standard cancer cell lines (A549MDA‐MB‐231, HT‐29) revealing good anticancer activity of all three complexes.
Topics & Concepts
ChemistryHomolepticMesoionicSeleniumStereochemistryCrystallographyMetalCoordination complexPolarCombinatorial chemistryInorganic chemistryMedicinal chemistryOrganic chemistryPhysicsAstronomyOrganometallic Complex Synthesis and CatalysisMetal complexes synthesis and propertiesOrganometallic Compounds Synthesis and Characterization