Targeting Aurora B kinase prevents and overcomes resistance to EGFR inhibitors in lung cancer by enhancing BIM- and PUMA-mediated apoptosis
Kosuke Tanaka, Helena A. Yu, Shaoyuan Yang, Song Han, S. Duygu Selçuklu, Kwanghee Kim, Shriram Ramani, Yogesh Tengarai Ganesan, Allison Moyer, S. K. Sinha, Yuchen Xie, Kota Ishizawa, Hatice U. Osmanbeyoglu, Yang Lyu, Nitin Roper, Udayan Guha, Charles M. Rudin, Mark G. Kris, James J. Hsieh, Emily H. Cheng
Topics & Concepts
PumaAurora inhibitorCancer researchKinaseMitotic catastropheAurora kinaseApoptosisLung cancerCancer cellOsimertinibAurora A kinaseCancerBiologyEpidermal growth factor receptorMedicineCell biologyCell cycleErlotinibOncologyGeneticsBiochemistryMicrotubule and mitosis dynamicsCancer-related Molecular PathwaysProtein Degradation and Inhibitors