Astragalus mongholicus polysaccharides ameliorate hepatic lipid accumulation and inflammation as well as modulate gut microbiota in NAFLD rats
Mingyue Zhong, Yan Yan, Hai‐Sheng Yuan, A. Rong, Guoquan Xu, Fujuan Cai, Yuning Yang, Yuzhen Wang, Wenguang Zhang
Abstract
. mAPS supplementation had little effect on the profile of fecal short-chain fatty acids (SCFAs), but it significantly decreased the expression of colonic and hepatic G-protein coupled receptor (GPR) 41 and 43. Therefore, mAPS supplementation ameliorates hepatic inflammation and lipid accumulation in NAFLD by modulating the gut microbiota and SCFA-GPR signaling pathways. The present study provides new evidence for mAPS as a natural active substance in the treatment of NAFLD.
Topics & Concepts
EndocrinologyInternal medicineFatty liverProinflammatory cytokineLipid metabolismBiologyInsulin resistanceSteatosisInflammationDysbiosisAMPKLiver X receptorNonalcoholic fatty liver diseaseLiver X receptor alphaGut floraBiochemistryProtein kinase AKinaseNuclear receptorInsulinMedicineDiseaseGeneTranscription factorLiver Disease Diagnosis and TreatmentGut microbiota and healthDiet, Metabolism, and Disease