One-Pot Synthesis of α,β-Unsaturated γ-Lactones and Lactams via a Sequential <i>trans</i>-Hydroalumination and Catalytic Carboxylation of Propargyl Alcohols and Amines with Carbon Dioxide
Woo‐Jin Yoo, Wenlong Chen, Thanh V. Q. Nguyen, Shu̅ Kobayashi
Abstract
A one-pot, sequential process that combines a trans-selective hydroalumination of propargyl alcohols and amines with a copper- or silver-catalyzed carboxylation reaction using carbon dioxide, followed by an acid-mediated intramolecular condensation step, led to the formation of a wide range of α,β-unsaturated γ-butyrolactones and lactams.
Topics & Concepts
CarboxylationChemistryPropargylCatalysisIntramolecular forceCarbon dioxidePropargyl alcoholOrganic chemistryCondensationCarbonylationMedicinal chemistryCarbon monoxideThermodynamicsPhysicsCarbon dioxide utilization in catalysisAsymmetric Hydrogenation and CatalysisCatalytic Alkyne Reactions