A metformin-based nanoreactor alleviates hypoxia and reduces ATP for cancer synergistic therapy
Xiangyu Meng, Jia Song, Yunfeng Lei, Xuezhong Zhang, Zhixin Chen, Zhuoxuan Lu, Liming Zhang, Zhifei Wang
Abstract
assays indicate that MCGPD ∼ RGD NPs have excellent ability to promote cell apoptosis and to inhibit tumor growth. Overall, this smart responsive hydrogel nanosystem with hypoxia-relieving capacity and ATP-decreasing performance provides a promising strategy against cancer.
Topics & Concepts
Photodynamic therapyChemistryTumor microenvironmentPhotothermal therapyCancer researchDoxorubicinTumor hypoxiaIn vivoCancer cellMatrix metalloproteinaseHypoxia (environmental)GelatinApoptosisPharmacologyCancerChemotherapyBiochemistryRadiation therapyMedicineTumor cellsNanotechnologyOxygenBiologyMaterials scienceInternal medicineSurgeryOrganic chemistryBiotechnologyNanoplatforms for cancer theranosticsCancer, Hypoxia, and MetabolismAutophagy in Disease and Therapy