Empowering Retinal Gene Therapy with a Specific Promoter for Human Rod and Cone ON-Bipolar Cells
Elmar Carlos Hulliger, Simon Manuel Hostettler, Sonja Kleinlogel
Abstract
mouse model of late retinal degeneration. The new promoter enables precise manipulation of the inner retinal network and paves the way for clinical application of gene therapies for high-resolution optogenetic vision restoration, raising hopes of significantly improving the life quality of people suffering from blindness.
Topics & Concepts
RetinalGenetic enhancementCone (formal languages)GeneRetinaBiologyMedicineGeneticsOphthalmologyNeuroscienceComputer scienceAlgorithmRetinal Development and DisordersPhotoreceptor and optogenetics researchNeuroscience and Neural Engineering