Beyond Solvent Exclusion: i-Motif Detecting Capability and an Alternative DNA Light-Switching Mechanism in a Ruthenium(II) Polypyridyl Complex
Philip Spence, John Fielden, Zoë A. E. Waller
Abstract
has a preference for double-helical DNA. Finally, we propose a previously unreported light-switching mechanism that originates from steric compression and electronic effects in a tight binding site, as opposed to solvent exclusion. Our work suggests that many published non-emissive Ru complexes could potentially switch on in the presence biological targets with suitable binding sites, opening up a plethora of opportunity in the detection of biological molecules.
Topics & Concepts
ChemistryDNARutheniumSequence motifStereochemistryNucleic acidSteric effectsStructural motifCircular dichroismBiochemistryCatalysisDNA and Nucleic Acid ChemistryAdvanced biosensing and bioanalysis techniquesMetal complexes synthesis and properties