Paclitaxel-Loaded Cationic Fluid Lipid Nanodiscs and Liposomes with Brush-Conformation PEG Chains Penetrate Breast Tumors and Trigger Caspase-3 Activation
Lorena Simón‐Gracia, Pablo Scodeller, William S. Fisher, Valeria Sidorenko, Victoria M. Steffes, Kai K. Ewert, Cyrus R. Safinya, Tambet Teesalu
Abstract
was able to incorporate up to 2.5 mol % PTX without crystallization for at least 20 h. Remarkably, compared to preparations containing 2 and 5 mol % PEG5K-lipid (with the PEG chains in the mushroom regime), the particles at 10 mol % (with PEG chains in the brush regime) showed significantly higher blood half-life, tumor penetration, and proapoptotic activity. Our study suggests that increasing the PEG coverage of CL-based drug nanoformulations can improve their pharmacokinetics and therapeutic efficacy.
Topics & Concepts
Materials scienceLiposomePEG ratioPaclitaxelBrushCationic polymerizationBiophysicsCationic liposomeNanotechnologyBiochemistryPolymer chemistryChemistryTransfectionBiologyComposite materialCancerFinanceGeneticsEconomicsGeneNanoparticle-Based Drug DeliveryNanoplatforms for cancer theranosticsATP Synthase and ATPases Research