¹⁹ F NMR viewed through two different lenses: ligand-observed and protein-observed ¹⁹ F NMR applications for fragment-based drug discovery

Abstract

F NMR experiments tailored towards drug discovery with a focus on fragment screening. We also cover the key advances that have furthered the field in recent years, including quantitative, structural, and in-cell methodologies. Several case studies are described for each application to highlight areas for innovation and to further catalyze new NMR developments for using this versatile nucleus.

Topics & Concepts