The Vancomycin Resistance-Associated Regulatory System VraSR Modulates Biofilm Formation of Staphylococcus epidermidis in an <i>ica</i> -Dependent Manner
Youcong Wu, Yuanyuan Meng, Lian Qian, Baixing Ding, Haiyan Han, Hongling Chen, Li Bai, Di Qu, Yang Wu
Abstract
operon and directly regulates polysaccharide intercellular adhesin production and biofilm formation in S. epidermidis. Furthermore, VraSR may indirectly modulate bacterial cell death and extracellular DNA (eDNA) release in biofilms through the CidA-LrgAB system. This work provides a new molecular insight into the mechanisms of VraSR-mediated modulation of the biofilm formation and cell death of S. epidermidis.
Topics & Concepts
BiofilmStaphylococcus epidermidisVancomycinMicrobiologyStaphylococcusChemistryBiologyStaphylococcus aureusBacteriaGeneticsBacterial biofilms and quorum sensingAntimicrobial Resistance in StaphylococcusAntimicrobial Peptides and Activities