A novel glycosylated indolocarbazole derivative LCS1269 effectively inhibits growth of human cancer cells in vitro and in vivo through driving of both apoptosis and senescence by inducing of DNA damage and modulating of AKT/mTOR/S6K and ERK pathways
Nikolay N. Kalitin, Lidia V. Ektova, Natalia S. Kostritsa, Anastasia S. Sivirinova, Aleksandr Kostarev, Galina B. Smirnova, Yulia A. Borisova, И. С. Голубева, Elisaveta V. Ermolaeva, Maria Vergun, Maria A. Babaeva, А. А. Лушникова, А. Ф. Карамышева
Topics & Concepts
ApoptosisCell cycle checkpointIn vivoProtein kinase BCancer researchPI3K/AKT/mTOR pathwayCancer cellCell growthChemistryDNA damageCell cycleCell cultureMAPK/ERK pathwayA549 cellBiologyCancerCell biologySignal transductionBiochemistryDNABiotechnologyGeneticsBioactive Compounds and Antitumor AgentsCancer therapeutics and mechanismsGenomics, phytochemicals, and oxidative stress