Impact of Sex and Age on mRNA COVID-19 Vaccine-Related Side Effects in Japan
Masahiko Mori, Aiko Yokoyama, Ayami Shichida, Kimiko Sasuga, Takafumi Maekawa, Tadayoshi Moriyama
Abstract
We demonstrate sex- and age-related impact on mRNA COVID-19 vaccine-related side effects, with a higher number and frequency of side effects and prolonged time to recovery in females compared to males and negative correlation between age and vaccine-related side effects. Identification of unique age- and sex-specific adverse symptoms will provide the opportunity to better understand the nature of sex- and age-associated immunological differences and develop safer and more efficacious vaccines.
Topics & Concepts
Coronavirus disease 2019 (COVID-19)MedicineSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2)2019-20 coronavirus outbreakAdverse effectYoung adultDemographyBiologyImmunologyPhysiologyInternal medicineVirologyDiseaseOutbreakInfectious disease (medical specialty)SociologySARS-CoV-2 and COVID-19 ResearchImmunotherapy and Immune ResponsesMonoclonal and Polyclonal Antibodies Research