The Role of the Hedgehog Pathway in Chemoresistance of Gastrointestinal Cancers
Yabing Liang, Ling Yang, Jingwu Xie
Abstract
The hedgehog pathway, which plays a significant role in embryonic development and stem cell regulation, is activated in gastrointestinal cancers. Chemotherapy is widely used in cancer treatment. However, chemoresistance becomes a substantial obstacle in cancer therapy. This review focuses on the recent advances in the hedgehog pathway's roles in drug resistance of gastrointestinal cancers and the novel drugs and strategies targeting hedgehog signaling.
Topics & Concepts
HedgehogHedgehog signaling pathwayCancerCancer researchBiologyGastrointestinal cancerSonic hedgehogChemotherapyMedicineEmbryonic stem cellBioinformaticsSignal transductionInternal medicineColorectal cancerGeneticsGeneHedgehog Signaling Pathway StudiesPancreatic and Hepatic Oncology ResearchEpigenetics and DNA Methylation