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Efficacy and safety of once-daily oral orforglipron compared with oral semaglutide in adults with type 2 diabetes (ACHIEVE-3): a multinational, multicentre, non-inferiority, open-label, randomised, phase 3 trial

Julio Rosenstock, Daisuke Yabe, David A. Cox, Jianghao Li, Max Denning, Wen-Shuo Wu, Rong Liu, Youna Zhao, Federico Pérez Manghi, Franklin Ábalos, P. Costanzo, Ana Chiesa, Natacha Maldonado, Susana Salzberg, Claudia Goycoa, Horacio Sessa, Diego Aizenberg, Marisa L. Vico, Fernando Guerlloy, María Schiavoni, Mariano I. Chahin, Adriana Villarino, Ines Bartolacci, Adrian Hernandez Gauna, Marcos Mayer, Shunbin Li, Zhenmei An, Jianhua Ma, Shu Li, Jian Zhou, Guoyue Yuan, YIBING LU, Hongman Wang, Qingju Li, Xinyu Li, Tian Feng Wu, Xiaozhen Jiang, Yawei Zhang, Yufeng Li, Hong Zhu, Yihua Wang, Hongwei Jiang, Jie Shen, XIAOLIN DONG, ZhiFeng Cheng, Tetsuji Niiya, Shinya Nakamoto, NOBUYUKI SATO, Masahiko Takai, T. Kato, Toshihiko Shiraiwa, Hidenori Bando, Akira Ohishi, Takeshi Osonoi, Melchor Alpizar Salazar, Pedro Garcia Hernandez, Elías Alberto García Cantú, Manuel de los Rios Ibarra, Emilia Pelayo Orozco, Maria Arechavaleta Granell, José Lazcano Soto, Luis Virgen Carrillo, Laura Castro Castrezana, Silvia Ramos, Arnulfo Gonzalez, Carlos Alejandro Stobschinski de Alba, Ramiro Banda Elizondo, Raymundo García Reza, Raymundo García Reza, Jose Gerardo Gonzalez Gonzalez, Yshay Shlesinger, Jawad Sarwar, Sumana Gangi, Bram Wieskopf, Thaidra Gaufin, Rachel Anderson, Eric Garcia-Torres, Eduardo Luna, Peter Philander, Christopher Chow, Sridhar Guduri, Alex Gonzalez-Bossolo, Brock McConnehey, Lisa S. Usdan, Donald Brautigam, Donald Brautigam, Michael Adams, Alison Schneider, Dennis Tsang, Peter Mattar, Talessa Powell, Paola Mansilla-Letelier, Lisa Connery, Reynaldo Lopez, Robert Buynak, Damaris Vega, Juan Loy, Herbert Conaway, James Schultz, John H. Kim

2026The Lancet13 citationsDOI

Topics & Concepts

MedicineSemaglutideType 2 diabetesInternal medicineClinical trialDiabetes mellitusPhases of clinical researchPhase (matter)Oral administrationRandomized controlled trialDiabetes Treatment and ManagementDiabetes, Cardiovascular Risks, and LipoproteinsHyperglycemia and glycemic control in critically ill and hospitalized patients
Efficacy and safety of once-daily oral orforglipron compared with oral semaglutide in adults with type 2 diabetes (ACHIEVE-3): a multinational, multicentre, non-inferiority, open-label, randomised, phase 3 trial | Litcius