SAR study of 4-arylazo-3,5-diamino-1<i>H</i>-pyrazoles: identification of small molecules that induce dispersal of <i>Pseudomonas aeruginosa</i> biofilms
Charlotte Uldahl Jansen, Jesper Uhd, Jens Bo Andersen, Louise Dahl Hultqvist, Tim Holm Jakobsen, Martin Nilsson, Thomas E. Nielsen, Michael Givskov, Tim Tolker‐Nielsen, Katrine Qvortrup
Abstract
By screening of a collection of 50 000 small-molecule compounds, we recently identified 4-arylazo-3,5-diamino-1 H -pyrazoles as a novel group of anti-biofilm agents.
Topics & Concepts
Pseudomonas aeruginosaBiological dispersalIdentification (biology)BiofilmMicrobiologyPseudomonadaceaeChemistryBiologyBacteriaEcologyGeneticsMedicinePopulationEnvironmental healthbioluminescence and chemiluminescence researchBacterial biofilms and quorum sensingAntimicrobial agents and applications