Formulation of simvastatin chitosan nanoparticles for controlled delivery in bone regeneration: Optimization using Box-Behnken design, stability and in vivo study
Wisam Khalaf Delan, Mai Zakaria, Basma Elsaadany, Aliaa Nabil ElMeshad, Wael Mamdouh, Ahmed Fares
Topics & Concepts
SimvastatinChitosanBox–Behnken designDispersityNanoparticleBiomedical engineeringZeta potentialParticle sizeMaterials scienceIn vivoChemistryChromatographyNanotechnologyResponse surface methodologyPharmacologyMedicineBiochemistryPolymer chemistryBiotechnologyBiologyPhysical chemistryBone Tissue Engineering MaterialsNanoparticle-Based Drug DeliveryAdvanced Drug Delivery Systems