Sustainable and Affordable Synthesis of (Deuterated) <i>N</i>-Methyl/Ethyl Amines from Nitroarenes
Akash Mondal, Abhijith Karattil Suresh, Ganesan Sivakumar, Ekambaram Balaraman
Abstract
The sustainable and affordable synthesis of (deuterated) N-methyl/ethyl amines directly from nitroarenes is disclosed. The reaction is catalyzed by a single-site manganese catalyst and involves tandem dehydrogenation, transfer hydrogenation, and borrowing hydrogenation. This catalytic protocol is highly selective and provides a facile method for the large-scale synthesis of a series of N-CH3/N-CD3 aniline derivatives with excellent functional group tolerance.
Topics & Concepts
ChemistryAnilineCatalysisDehydrogenationDeuteriumTandemTransfer hydrogenationManganeseCombinatorial chemistryFunctional groupOrganic chemistryMedicinal chemistryRutheniumPolymerPhysicsMaterials scienceQuantum mechanicsComposite materialChemical Reactions and IsotopesAsymmetric Hydrogenation and CatalysisAmmonia Synthesis and Nitrogen Reduction