Codelivery of CRISPR-Cas9 and chlorin e6 for spatially controlled tumor-specific gene editing with synergistic drug effects
Shaohui Deng, Mingqiang Li, Shuang Liu, Jifeng Chen, Mingqiang Li, Sing Yian Chew, Kam W. Leong, Du Cheng
Abstract
gene editing were confirmed in vivo. Controlled release of CRISPR-Cas9 RNP and codelivery with Ce6 using stimuli-responsive nanoparticles represent a versatile strategy for gene editing with potentially synergistic drug effects.
Topics & Concepts
CRISPRGenome editingDrug targetDrugCas9GeneComputational biologyChlorinBiologyChemistryCancer researchPhotodynamic therapyGeneticsPharmacologyOrganic chemistryCRISPR and Genetic EngineeringAdvanced biosensing and bioanalysis techniquesRNA Interference and Gene Delivery