Secretion into Milk of the Main Metabolites of the Anthelmintic Albendazole Is Mediated by the ABCG2/BCRP Transporter
Esther Blanco–Paniagua, Laura Álvarez–Fernández, Alba M. García‐Lino, Ana I. Álvarez, Gracia Merino
Abstract
Albendazole (ABZ) is an anthelmintic with a broad-spectrum activity, widely used in human and veterinary medicine. ABZ is metabolized in all mammalian species to albendazole sulfoxide (ABZSO), albendazole sulfone (ABZSO 2 ) and albendazole 2-aminosulphone (ABZSO 2 -NH 2 ).
Topics & Concepts
AlbendazoleAnthelminticPharmacologyOxfendazoleBenzimidazoleTransporterChemistryBiologyMedicineBiochemistryFenbendazoleVeterinary medicineEcologyGeneOrganic chemistryDrug Transport and Resistance MechanismsHelminth infection and controlParasites and Host Interactions