Electrochemical synthesis of CN-substituted imidazo[1,5-a]pyridines via a cascade process using NH4SCN as both an electrolyte and a non-trivial cyanating agent

Sergei S. Grishin, Olga M. Mulina, Vera A. Vil’, Alexander O. Terent’ev

2023Organic Chemistry Frontiers16 citationsDOI

Abstract

An electrochemical cascade of oxidation/cyclization of pyridine-2-carboxaldehydes with benzylamines involving in situ cyanation with NH 4 SCN to afford 1-cyano-imidazo[1,5- a ]pyridines was developed.

Topics & Concepts

ChemistryElectrochemistryCyanationPyridineCascadeSupporting electrolyteElectrolyteCombinatorial chemistryMedicinal chemistryElectrodeOrganic chemistryPhysical chemistryCatalysisChromatographyCatalytic C–H Functionalization MethodsRadical Photochemical ReactionsSulfur-Based Synthesis Techniques

Electrochemical synthesis of CN-substituted imidazo[1,5-<i>a</i>]pyridines <i>via</i> a cascade process using NH<sub>4</sub>SCN as both an electrolyte and a non-trivial cyanating agent

Abstract

Topics & Concepts