Tracking the ATP-binding response in adenylate kinase in real time
Fredrik Orädd, H. Ravishankar, Jack Goodman, Per Rogne, Lars Backman, Annette Duelli, Martin Nors Pedersen, Matteo Levantino, Michaël Wulff, Magnus Wolf‐Watz, Magnus Andersson
Abstract
Ala AdK mutant, which refolded in a closed, substrate-binding conformation. The observed structural dynamics agree with a “cracking mechanism” proposed to underlie global structural transformation, such as allostery, in proteins.
Topics & Concepts
Adenylate kinaseTracking (education)EnzymeKinaseChemistryBiophysicsBiochemistryBiological systemCell biologyComputational biologyBiologyPsychologyPedagogyProtein Structure and DynamicsEnzyme Structure and FunctionComputational Drug Discovery Methods