Four-dimensional computational ultrasound imaging of brain hemodynamics
Michael Brown, Bastian S. Generowicz, Stéphanie Dijkhuizen, Sebastiaan K. E. Koekkoek, Christos Strydis, Johan G. Bosch, Petros Arvanitis, Geert Springeling, Geert Leus, Chris I. De Zeeuw, Pieter Kruizinga
Abstract
Four-dimensional ultrasound imaging of complex biological systems such as the brain is technically challenging because of the spatiotemporal sampling requirements. We present computational ultrasound imaging (cUSi), an imaging method that uses complex ultrasound fields that can be generated with simple hardware and a physical wave prediction model to alleviate the sampling constraints. cUSi allows for high-resolution four-dimensional imaging of brain hemodynamics in awake and anesthetized mice.
Topics & Concepts
UltrasoundComputer scienceSampling (signal processing)Ultrasound imagingNeuroimagingArtificial intelligenceComputer visionNeuroscienceMedicineRadiologyPsychologyFilter (signal processing)Ultrasound Imaging and ElastographyPhotoacoustic and Ultrasonic ImagingMicrowave Imaging and Scattering Analysis