Association of gut microbiota composition and function with an aged rat model of senile osteoporosis using 16S rRNA and metagenomic sequencing analysis
Sicong Ma, Jinhong Qin, Yongqiang Hao, Lingjie Fu
Abstract
was potentially related to osteoporosis as a risk factor. Metagenomics results based on two databases indicated that shifts in the GM contribute to senile osteoporosis through metabolic pathways and subsequent immune disorders. In conclusion, our study reveals the association of gut microbiota composition and function with senile osteoporosis in an aged rat model in a brand new way, and variations in the GM might contribute to senile osteoporosis through metabolic pathways.
Topics & Concepts
OsteoporosisMetagenomicsSenile osteoporosisGut floraFirmicutesDysbiosisBacteroidetesBiologyMedicineInternal medicineImmunologyGenetics16S ribosomal RNABacteriaGeneGut microbiota and healthClostridium difficile and Clostridium perfringens researchHelicobacter pylori-related gastroenterology studies