Temporal multi-omics identifies LRG1 as a vascular niche instructor of metastasis
Mahak Singhal, Nicolas Gengenbacher, Ashik Ahmed Abdul Pari, Miki Kamiyama, Ling Hai, Bianca J. Kuhn, David Kallenberg, Shubhada R. Kulkarni, Carlotta Camilli, Stephanie F. Preuß, Barbara Leuchs, Carolin Mogler, Elisa Espinet, Eva Besemfelder, Danijela Heide, Mathias Heikenwälder, Martin R. Sprick, Andreas Trumpp, Jeroen Krijgsveld, Matthias Schlesner, Junhao Hu, Stephen E. Moss, John Greenwood, Hellmut G. Augustin
Abstract
hampered growth of lung metastasis. Postsurgical adjuvant administration of an LRG1-neutralizing antibody delayed metastatic growth and increased overall survival. This study has established a systems map of early primary tumor-induced vascular changes and identified LRG1 as a therapeutic target for metastasis.
Topics & Concepts
MetastasisCancer researchBiologyPrimary tumorMatricellular proteinCancerImmunologyMedicineCell biologyExtracellular matrixGeneticsClusterin in disease pathologyFerroptosis and cancer prognosisBiomarkers in Disease Mechanisms