Repetitive sulfur dioxide exposure in mice models post-deployment respiratory syndrome
Sergey Gutor, Rodrigo I. Salinas, David S. Nichols, Julia Miranda R. Bazzano, Wei Han, Jason J. Gokey, Georgii Vasiukov, James West, Dawn C. Newcomb, Anna Dikalova, Bradley W. Richmond, Sergey Dikalov, Timothy S. Blackwell, Vasiliy V. Polosukhin
Abstract
We developed a mice model of "post-deployment respiratory syndrome" (PDRS), a condition in Veterans with unexplained exertional dyspnea. Our model successfully recapitulates many of the pathological and physiological features of the syndrome, revealing involvement of the ROS-isoLGs-Sirt3-SOD2 pathway in pulmonary vasculature pathology. Our study provides additional knowledge about effects and long-term consequences of sulfur dioxide exposure on the respiratory system, serving as a valuable tool for future PDRS research.