Impact of aqueous micellar media on biocatalytic transformations involving transaminase (ATA); applications to chemoenzymatic catalysis
Jade Dussart‐Gautheret, Tzu‐Yu Yu, Krithika Ganesh, Gaikwad Rajendra, Fabrice Gallou, Bruce H. Lipshutz
Abstract
Surfactant-enabled asymmetric ATA-catalyzed reductive aminations in aqueous buffered media are described, representative of the enhanced levels of conversion made possible by the presence of a nonionic surfactant in the water, thereby enabling 1-pot chemoenzymatic catalysis.
Topics & Concepts
Aqueous mediumCatalysisChemistryPulmonary surfactantAqueous solutionOrganic chemistryTransaminaseEnantioselective synthesisCombinatorial chemistryEnzymeBiochemistryEnzyme Catalysis and ImmobilizationAsymmetric Hydrogenation and CatalysisChemical Synthesis and Analysis