The endoplasmic reticulum kinase PERK interacts with the oxidoreductase ERO1 to metabolically adapt mitochondria
Arthur Bassot, Junsheng Chen, Kei Takahashi-Yamashiro, Megan C. Yap, Christine S. Gibhardt, Giang N. T. Le, Saaya Hario, Yusuke Nasu, Jack Moore, Tomás Gutiérrez, Lucas Mina, Heather Mast, Audric S. Moses, Rakesh Bhat, Klaus Ballanyi, Hélène Lemieux, Roberto Sitia, Ester Zito, Ivan Bogeski, Robert E. Campbell, Thomas Simmen
Abstract
flux to maintain bioenergetics in both organelles, while limiting oxidative stress. Therefore, the PERK-ERO1⍺ complex is a key molecular machinery that allows quick metabolic adaptation to ER stress.
Topics & Concepts
Endoplasmic reticulumUnfolded protein responseMitochondrionCell biologyCalnexinBioenergeticsBiochemistryChemistryBiologyCalreticulinMitochondrial Function and PathologyEndoplasmic Reticulum Stress and DiseaseATP Synthase and ATPases Research