CHI3L1 in the pathophysiology and diagnosis of liver diseases
Shuwei Wang, Meng‐Yuan Hu, Yun-Song Qian, Zhenluo Jiang, Lili Shen, Liyun Fu, Yaoren Hu
Abstract
Chitinase 3-like protein 1(CHI3L1) participates in physiological and pathophysiological process, such as cell survival, cell proliferation, tissue remodeling, angiogenesis, etc. Some studies demonstrated that CHI3L1 is liver-enriched and has better application value in staging liver fibrosis than platelet ratio index(APRI) and fibrosis-4 index(FIB-4) and that CHI3L1 can be used in monitoring the prognosis of hepatocellular carcinoma (HCC). In this review, we summarized the pathophysiological role and the diagnostic value of CHI3L1 in liver fibrosis in different background and HCC.
Topics & Concepts
PathophysiologyAngiogenesisHepatocellular carcinomaMedicineFibrosisHepatic fibrosisLiver fibrosisPathologyCancer researchInternal medicineStudies on Chitinases and ChitosanasesGalectins and Cancer BiologyPeptidase Inhibition and Analysis