Litcius/Paper detail

Discovery of novel β-carboline derivatives as selective AChE inhibitors with GSK-3β inhibitory property for the treatment of Alzheimer's disease

Wenwu Liu, Xin Liu, Wenjie Liu, Yaping Gao, Limeng Wu, Yaoguang Huang, Huanhua Chen, Deping Li, Lijun Zhou, Nan Wang, Zihua Xu, Xiaowen Jiang, Qingchun Zhao

2021European Journal of Medicinal Chemistry45 citationsDOIOpen Access PDF

Topics & Concepts

HarmineChemistryPeganum harmalaButyrylcholinesteraseAcetylcholinesteraseGSK-3StereochemistryIC50Docking (animal)Structure–activity relationshipBiochemistryKinaseAchéEnzymePharmacologyIn vitroTraditional medicineNursingMedicineCholinesterase and Neurodegenerative DiseasesSynthesis and bioactivity of alkaloidsComputational Drug Discovery Methods