Enhanced Pathogenesis Caused by Influenza D Virus and Mycoplasma bovis Coinfection in Calves: a Disease Severity Linked with Overexpression of IFN-γ as a Key Player of the Enhanced Innate Immune Response in Lungs
Adrien Lion, Aurélie Sécula, Camille Rançon, Olivier Boulesteix, Anne Pinard, Alain Deslis, Sara Hägglund, Elias Salem, Hervé Cassard, Katarina Näslund, Maria Gaudino, Ana Moreno, Emiliana Brocchi, Maxence Delverdier, Siamak Zohari, Éric Baranowski, Jean-François Valarcher, Mariette Ducatez, Gilles Meyer
Abstract
gene in particular was highly overexpressed after coinfection, correlated with the disease severity, immune response, and white cell recruitment in the lungs. In conclusion, we showed that IDV facilitates coinfections within the BRD complex by modulating the local innate immune response, providing new insights into the mechanisms involved in severe respiratory diseases.
Topics & Concepts
CoinfectionInnate immune systemBiologyImmunologyImmune systemPathogenVirologyVirusPathogenesisInfluenza A virusMicrobiologyMicrobial infections and disease researchAnimal Disease Management and EpidemiologyVector-Borne Animal Diseases