Stereoselective synthesis of Gly-Gly-type (<i>E</i>)-methylalkene and (<i>Z</i>)-chloroalkene dipeptide isosteres and their application to 14-mer RGG peptidomimetics
Hikari Okita, Yuna Kato, Tatsuki Masuzawa, Kosuke Arai, Sayuri Takeo, Kohei Sato, Nobuyuki Mase, Takanori Oyoshi, Tetsuo Narumi
Abstract
An efficient synthesis of Gly-Gly-type (<italic>E</italic>)-methylalkene and (<italic>Z</italic>)-chloroalkene dipeptide isosteres is realized by organocuprate-mediated single electron transfer reduction.
Topics & Concepts
PeptidomimeticDipeptideStereoselectivityChemistryStereochemistryPeptideAmino acidPeptide synthesisCombinatorial chemistryOrganic chemistryCatalysisBiochemistryChemical Synthesis and AnalysisRNA and protein synthesis mechanismsClick Chemistry and Applications